New research suggests that gabapentin, a medication used by millions for pain and seizures, could be tied to a higher risk of dementia. The study, published by Case Western Reserve University, analyzed data from thousands of patients and found a troubling pattern.
Patients who took gabapentin six or more times had a 29% increased risk of dementia within a decade, while those with twelve or more prescriptions faced a 40% higher risk. Mild cognitive impairment, often an early sign of dementia, was even more strongly associated, with frequent users seeing an 85% rise in risk.
The study found that middle-aged adults (35-49) were most affected, with their dementia risk more than doubling. Younger patients (18-34) showed no significant increase, raising questions about how age influences the drug’s effects. However, researchers emphasize that the findings only show a possible link—not definitive proof of causation.
Experts have pointed out gaps in the study. It didn’t track exact dosages or account for other risk factors, such as inactivity in chronic pain patients. Dr. Leah Mursaleen of Alzheimer’s Research UK noted that while the study is important, more research is needed to confirm any connection.
Gabapentin works by stabilizing nerve activity, but its long-term impact on brain health remains uncertain. Despite the concerns, doctors advise patients not to discontinue the drug without medical guidance, as untreated conditions could pose greater risks.
